Genome-scale metabolic reconstruction of 7,302 human microorganisms for personalized medicine.

ABSTRACT: The human microbiome influences the efficacy and safety of a wide variety of commonly prescribed drugs. Designing precision medicine approaches that incorporate microbial metabolism would require strain- and molecule-resolved, scalable computational modeling. Here, we extend our previous resource of genome-scale metabolic reconstructions of human gut microorganisms with a greatly expanded version. AGORA2 (assembly of gut organisms through reconstruction and analysis, version 2) accounts for 7,302 strains, includes strain-resolved drug degradation and biotransformation capabilities for 98 drugs, and was extensively curated based on comparative genomics and literature searches. The microbial reconstructions performed very well against three independently assembled experimental datasets with

SUBMITTER: Heinken A 

PROVIDER: S-EPMC10497413 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature