Experimental and theoretical model for the origin of coiling of cellular protrusions around fibers.

ABSTRACT: Protrusions at the leading-edge of a cell play an important role in sensing the extracellular cues during cellular spreading and motility. Recent studies provided indications that these protrusions wrap (coil) around the extracellular fibers. However, the physics of this coiling process, and the mechanisms that drive it, are not well understood. We present a combined theoretical and experimental study of the coiling of cellular protrusions on fibers of different geometry. Our theoretical model describes membrane protrusions that are produced by curved membrane proteins that recruit the protrusive forces of actin polymerization, and identifies the role of bending and adhesion energies in orienting the leading-edges of the protrusions along the azimuthal (coiling) direction. Our model predic

SUBMITTER: Sadhu RK 

PROVIDER: S-EPMC10497540 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature