Baseline levels of miR-223-3p correlate with the effectiveness of electroconvulsive therapy in patients with major depression.

ABSTRACT: There is a strong medical need to develop suitable biomarkers to improve the diagnosis and treatment of depression, particularly in predicting response to certain therapeutic approaches such as electroconvulsive therapy (ECT). MicroRNAs are small non-coding RNAs that have the ability to influence the transcriptome as well as proteostasis at the systems level. Here, we investigate the role of circulating microRNAs in depression and response prediction towards ECT. Of the 64 patients with treatment-resistant major depression (MDD) who received ECT treatment, 62.5% showed a response, defined as a reduction of ≥50% in the MADRS total score from baseline. We performed smallRNA sequencing in blood samples that were taken before the first ECT, after the first and the last ECT. The microRNAome was

SUBMITTER: Kaurani L 

PROVIDER: S-EPMC10497550 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature