Comprehensive analysis of copper-metabolism-related genes about prognosis and immune microenvironment in osteosarcoma.

ABSTRACT: Despite being significant in various diseases, including cancers, the impact of copper metabolism on osteosarcoma (OS) remains largely unexplored. This study aimed to use bioinformatics analyses to identify a reliable copper metabolism signature that could improve OS patient prognosis prediction, immune landscape understanding, and drug sensitivity. Through nonnegative matrix factorization (NMF) clustering, we revealed distinct prognosis-associated clusters of OS patients based on copper metabolism-related genes (CMRGs), showing differential gene expression linked to immune processes. The risk model, comprising 13 prognostic CMRGs, was established using least absolute shrinkage and selection operator (LASSO) Cox regression, closely associated with the OS microenvironment's immune situation

SUBMITTER: Lin Z 

PROVIDER: S-EPMC10497601 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature