Removal of calciprotein particles from the blood using an adsorption column improves prognosis of hemodialysis miniature pigs.

ABSTRACT: Hyperphosphatemia is a major risk for poor prognosis in patients with end-stage renal disease. However, the molecular mechanism behind this link remains elusive. We and others have demonstrated that serum phosphorus levels correlate positively with circulating levels of calciprotein particles (CPPs). CPPs are colloidal mineral-protein complexes containing insoluble calcium-phosphate precipitates and have been reported to induce calcification in cultured vascular smooth muscle cells and inflammatory responses in cultured macrophages. Hence, we hypothesize that CPPs may be responsible for disorders associated with hyperphosphatemia. Using hyperphosphatemic miniature pigs receiving hemodialysis, here we show that removal of CPPs from the blood with a newly developed CPP adsorption column impr

SUBMITTER: Miura M 

PROVIDER: S-EPMC10497634 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature