Decoding of translation-regulating entities reveals heterogeneous translation deficiency patterns in cellular senescence.

ABSTRACT: Cellular senescence constitutes a generally irreversible proliferation barrier, accompanied by macromolecular damage and metabolic rewiring. Several senescence types have been identified based on the initiating stimulus, such as replicative (RS), stress-induced (SIS) and oncogene-induced senescence (OIS). These senescence subtypes are heterogeneous and often develop subset-specific phenotypes. Reduced protein synthesis is considered a senescence hallmark, but whether this trait pertains to various senescence subtypes and if distinct molecular mechanisms are involved remain largely unknown. Here, we analyze large published or experimentally produced RNA-seq and Ribo-seq datasets to determine whether major translation-regulating entities such as ribosome stalling, the presence of uORFs/dORFs

SUBMITTER: Papaspyropoulos A 

PROVIDER: S-EPMC10497830 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature