The role of aging and brain-derived neurotrophic factor signaling in expression of base excision repair genes in the human brain.

ABSTRACT: DNA damage is a central contributor to the aging process. In the brain, a major threat to the DNA is the considerable amount of reactive oxygen species produced, which can inflict oxidative DNA damage. This type of damage is removed by the base excision repair (BER) pathway, an essential DNA repair mechanism, which contributes to genome stability in the brain. Despite the crucial role of the BER pathway, insights into how this pathway is affected by aging in the human brain and the underlying regulatory mechanisms are very limited. By microarray analysis of four cortical brain regions from humans aged 20-99 years (n = 57), we show that the expression of core BER genes is largely downregulated during aging across brain regions. Moreover, we find that expression of many BER genes correlates

SUBMITTER: Lautrup S 

PROVIDER: S-EPMC10497833 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature