Circadian regulation in aging: Implications for spaceflight and life on earth.

ABSTRACT: Alterations in the circadian system are characteristic of aging on Earth. With the decline in physiological processes due to aging, several health concerns including vision loss, cardiovascular disorders, cognitive impairments, and muscle mass loss arise in elderly populations. Similar health risks are reported as "red flag" risks among astronauts during and after a long-term Space exploration journey. However, little is known about the common molecular alterations underlying terrestrial aging and space-related aging in astronauts, and controversial conclusions have been recently reported. In light of the regulatory role of the circadian clock in the maintenance of human health, we review here the overlapping role of the circadian clock both on aging on Earth and spaceflight with a focus o

SUBMITTER: Malhan D 

PROVIDER: S-EPMC10497835 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature