Cellular immunity to SARS-CoV-2 following intrafamilial exposure in seronegative family members.

ABSTRACT:

Introduction

Family studies of antiviral immunity provide an opportunity to assess virus-specific immunity in infected and highly exposed individuals, as well as to examine the dynamics of viral infection within families. Transmission of SARS-CoV-2 between family members represented a major route for viral spread during the early stages of the pandemic, due to the nature of SARS-CoV-2 transmission through close contacts.

Methods

Here, humoral and cellular immunity is explored in 264 SARS-CoV-2 infected, exposed or unexposed individuals from 81 families in the United Kingdom sampled in the winter of 2020 before widespread vaccination and infection.

Results

We describe robust cellular and humoral immunity into COVID-19 convalescence, albeit with marked heterogeneity bet

SUBMITTER: Jay C 

PROVIDER: S-EPMC10497976 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature