FAM122A Is Required for Mesendodermal and Cardiac Differentiation of Embryonic Stem Cells.

ABSTRACT: Mesendodermal specification and cardiac differentiation are key issues for developmental biology and heart regeneration medicine. Previously, we demonstrated that FAM122A, a highly conserved housekeeping gene, is an endogenous inhibitor of protein phosphatase 2A (PP2A) and participates in multifaceted physiological and pathological processes. However, the in vivo function of FAM122A is largely unknown. In this study, we observed that Fam122 deletion resulted in embryonic lethality with severe defects of cardiovascular developments and significantly attenuated cardiac functions in conditional cardiac-specific knockout mice. More importantly, Fam122a deficiency impaired mesendodermal specification and cardiac differentiation from mouse embryonic stem cells but showed no influence on pluripot

SUBMITTER: Yang YS 

PROVIDER: S-EPMC10498146 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature