Dynamic ⁶⁸Ga-DOTA⁰-Tyr³-octreotate positron emission tomography-computed tomography for the evaluation of pancreatic neuroendocrine tumors: a pilot study.

ABSTRACT:

Background

⁶⁸Ga-DOTA⁰-Tyr³-octreotate (⁶⁸Ga-DOTATATE) is a radiolabeled somatostatin analog used for the diagnosis of pancreatic neuroendocrine tumors (pNETs), and standardized uptake value (SUV) measurements for therapeutic monitoring is recommended. However, changes in net influx rate (K_i) may better reflect treatment effects than may those of the SUV. The aim of this study was to investigate the value of dynamic ⁶⁸Ga-DOTATATE positron emission tomography-computed tomography (PET-CT) in the evaluation of pNETs.

Methods

Dynamic PET-CT scans over 60 min were acquired for 7 patients with localized pancreatic mass before surgery. Maximal and mean SUV (SUV_max and SUV_mean) were measured in tu

SUBMITTER: Yin H 

PROVIDER: S-EPMC10498240 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature