Association of KLK4 rs2235091 polymorphism with susceptibility to dental caries: a systematic review and meta-analysis.

ABSTRACT:

Objective

To investigate the association between Kallikrein-related peptidase-4 (KLK4) rs2235091 polymorphism and susceptibility to dental caries (DC) by a method of systematic review and meta-analysis.

Methods

Four English databases were searched for studies on the correlation between KLK4 rs2235091 polymorphism and susceptibility to DC from inception to April 1, 2023. Data analysis was processed by Stata 15.0 software.

Results

Four articles were eligible, including 848 individuals with caries and 463 controls. The results of pooled analysis showed no significant differences in the five gene models (G vs. A: odds ratio (OR) = 1.14, 95% CI: 0.73-1.79, P = 0.567; GG + GA vs. AA: OR = 1.01, 95% CI: 0.77-1.32, P = 0.489; GG vs. GA + AA: OR = 0.84, 95% CI: 0

SUBMITTER: Li Y 

PROVIDER: S-EPMC10498278 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature