Optomechanically Actuated Hydrogel Platform for Cell Stimulation with Spatial and Temporal Resolution.

ABSTRACT: Cells exist in the body in mechanically dynamic environments, yet the vast majority of in vitro cell culture is conducted on static materials such as plastic dishes and gels. To address this limitation, we report an approach to transition widely used hydrogels into mechanically active substrates by doping optomechanical actuator (OMA) nanoparticles within the polymer matrix. OMAs are composed of gold nanorods surrounded by a thermoresponsive polymer shell that rapidly collapses upon near-infrared (NIR) illumination. As a proof of concept, we crosslinked OMAs into laminin-gelatin hydrogels, generating up to 5 μm deformations triggered by NIR pulsing. This response was tunable by NIR intensity and OMA density within the gel and is generalizable to other hydrogel materials. Hydrogel me

SUBMITTER: Ramey-Ward AN 

PROVIDER: S-EPMC10498418 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature