Biodegradable Grubbs-Loaded Artificial Organelles for Endosomal Ring-Closing Metathesis.

ABSTRACT: The application of transition-metal catalysts in living cells presents a promising approach to facilitate reactions that otherwise would not occur in nature. However, the usage of metal complexes is often restricted by their limited biocompatibility, toxicity, and susceptibility to inactivation and loss of activity by the cell's defensive mechanisms. This is especially relevant for ruthenium-mediated reactions, such as ring-closing metathesis. In order to address these issues, we have incorporated the second-generation Hoveyda-Grubbs catalyst (HGII) into polymeric vesicles (polymersomes), which were composed of biodegradable poly(ethylene glycol)-b-poly(caprolactone-g-trimethylene carbonate) [PEG-b-P(CL-g-TMC)] block copolymers. The catalyst was either covalentl

SUBMITTER: Oerlemans RAJF 

PROVIDER: S-EPMC10498438 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature