Enhanced Pulley Effect for Translocation: The Interplay of Electrostatic and Hydrodynamic Forces.

ABSTRACT: Solid-state nanopore sensors remain a promising solution to the rising global demand for genome sequencing. These single-molecule sensing technologies require single-file translocation for high resolution and accurate detection. In a previous publication, we discovered a hairpin unraveling mechanism, namely, the pulley effect, in a pressure-driven translocation system. In this paper, we further investigate the pulley effect in the presence of pressure-driven fluid flow and an opposing force provided by an electrostatic field as an approach to increase single-file capture probability. A hydrodynamic flow is used to move the polymer forward, and two oppositely charged electrostatic square loops are used to create an opposing force. By optimizing the balance between forces, we show that the s

SUBMITTER: Afrasiabian N 

PROVIDER: S-EPMC10498446 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature