Neuroprotection by upregulation of the major histocompatibility complex class I (MHC I) in SOD1^G93A mice.

ABSTRACT: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that progressively affects motoneurons, causing muscle atrophy and evolving to death. Astrocytes inhibit the expression of MHC-I by neurons, contributing to a degenerative outcome. The present study verified the influence of interferon β (IFN β) treatment, a proinflammatory cytokine that upregulates MHC-I expression, in SOD1^G93A transgenic mice. For that, 17 days old presymptomatic female mice were subjected to subcutaneous application of IFN β (250, 1,000, and 10,000 IU) every other day for 20 days. Rotarod motor test, clinical score, and body weight assessment were conducted every third day throughout the treatment period. No significant intergroup variations were observed in such parameters during the pre-symp

SUBMITTER: Tomiyama ALMR 

PROVIDER: S-EPMC10498468 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature