Occupational factors and low back pain: a Mendelian randomization study.

ABSTRACT:

Background

Low back pain (LBP) is a common condition and a leading cause of health function loss worldwide. This study assessed the impact of occupational factors on LBP using Mendelian Randomization (MR) method, controlling for confounding variables.

Methods

Based on publicly available genome-wide association studies (GWAS), two-sample univariate and multivariate MR analyses were performed to assess the causal effect of occupational factors on LBP. We used the inverse variance weighted (IVW) method and sensitivity analyses to generate the total results for the univariate MR analysis. Furthermore, we performed multivariate MR analysis to assess the direct causal association between occupational factors and LBP after accounting for potential confounding variables.

Results<

SUBMITTER: Wang Z 

PROVIDER: S-EPMC10498534 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature