Analysis of circulating ceramides and hexosylceramides in patients with coronary artery disease and type II diabetes mellitus.

ABSTRACT:

Background

Cardiovascular disease (CVD) remains the leading cause of death worldwide. The main driving force behind this association is coronary artery disease (CAD), the manifestation of atherosclerosis in the coronary circulation. Cornerstones in the development of CAD are pathologies in lipid metabolism. In recent years, ongoing research has identified ceramides, a subclass of sphingolipids to be mediators of CVD. The aim of this study is to investigate the influence of type II diabetes mellitus (DM) on circulating ceramides and hexosylceramides (HexCers) in CAD patients.

Methods

24 patients aged 40-90 years with CAD confirmed by angiography were included into a pilot study. Patients with DM were identified by analysis of discharge letters or other medical documents avail

SUBMITTER: Dusing P 

PROVIDER: S-EPMC10498560 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature