Modelling porcine NAFLD by deletion of leptin and defining the role of AMPK in hepatic fibrosis.

ABSTRACT:

Background

Non-alcoholic fatty liver disease (NAFLD) is the most prevalent cause of chronic hepatic disease and results in non-alcoholic steatohepatitis (NASH), which progresses to fibrosis and cirrhosis. Although the Leptin deficient rodent models are widely used in study of metabolic syndrome and obesity, they fail to develop liver injuries as in patients.

Methods

Due to the high similarity with humans, we generated Leptin-deficient (Leptin^-/-) pigs to investigate the mechanisms and clinical trials of obesity and NAFLD caused by Leptin.

Results

The Leptin^-/- pigs showed increased body fat and significant insulin resistance at the age of 12 months. Moreover, Leptin^-/- pig developed fatty liver, non-alcoholic steatohepatitis and hepati

SUBMITTER: Tan T 

PROVIDER: S-EPMC10498639 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature