A systematic comparison of human mitochondrial genome assembly tools.

ABSTRACT:

Background

Mitochondria are the cell organelles that produce most of the chemical energy required to power the cell's biochemical reactions. Despite being a part of a eukaryotic host cell, the mitochondria contain a separate genome whose origin is linked with the endosymbiosis of a prokaryotic cell by the host cell and encode independent genomic information throughout their genomes. Mitochondrial genomes accommodate essential genes and are regularly utilized in biotechnology and phylogenetics. Various assemblers capable of generating complete mitochondrial genomes are being continuously developed. These tools often use whole-genome sequencing data as an input containing reads from the mitochondrial genome. Till now, no published work has explored the systematic comparison of all th

SUBMITTER: Mahar NS 

PROVIDER: S-EPMC10498642 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature