Protective effect of carbon dots derived from scrambled Coptidis Rhizoma against ulcerative colitis in mice.

ABSTRACT: Introduction: Ulcerative colitis (UC) is a chronic and progressive inflammatory disease of the intestines. The primary symptoms, such as bloody diarrhea, can result in weight loss and significantly diminish the patient's quality of life. Despite considerable research endeavors, this disease remains incurable. The scrambled Coptidis Rhizoma (SCR) has a rich historical background in traditional Chinese medicine as a remedy for UC. Drawing from a wealth of substantial clinical practices, this study is focused on investigating the protective effects and underlying mechanisms of the active component of SCR, namely SCR-based carbon dots (SCR-CDs), in the treatment of UC. Methods: SCR-CDs were extracted and isolated from the decoction of SCR, followed by a comprehensive chara

SUBMITTER: Mou Y 

PROVIDER: S-EPMC10498776 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature