Studying APOE ɛ4 Allele Dose Effects with a Univariate Morphometry Biomarker.

ABSTRACT:

Background

A univariate neurodegeneration biomarker (UNB) based on MRI with strong statistical discrimination power would be highly desirable for studying hippocampal surface morphological changes associated with APOE ɛ4 genetic risk for AD in the cognitively unimpaired (CU) population. However, existing UNB work either fails to model large group variances or does not capture AD induced changes.

Objective

We proposed a subspace decomposition method capable of exploiting a UNB to represent the hippocampal morphological changes related to the APOE ɛ4 dose effects among the longitudinal APOE ɛ4 homozygotes (HM, N = 30), heterozygotes (HT, N = 49) and non-carriers (NC, N = 61).

Methods

Rank minimization mechanism combined with sparse constraint considering the local conti

SUBMITTER: Wang G 

PROVIDER: S-EPMC10498787 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature