Steroid Components of Marine-Derived Fungal Strain Penicillium levitum N33.2 and Their Biological Activities.

ABSTRACT: Genus Penicillium comprising the most important and extensively studied fungi has been well-known as a rich source of secondary metabolites. Our study aimed to analyze and investigate biological activities, including in vitro anti-cancer, anti-inflammatory and anti-diabetic properties, of metabolites from a marine-derived fungus belonging to P. levitum. The chemical compounds in the culture broth of P. levitum strain N33.2 were extracted with ethyl acetate. Followingly, chemical analysis of the extract leaded to the isolation of three ergostane-type steroid components, namely cerevisterol (1), ergosterol peroxide (2), and (3β,5α,22E)-ergosta-6,8(14),22-triene-3,5-diol (3). Among these, (3) was the most potent cytotoxic against human c

SUBMITTER: Hoang CK 

PROVIDER: S-EPMC10498798 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature