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Serum Free Fatty Acid Changes Caused by High Expression of Stearoyl-CoA Desaturase 1 in Tumor Tissues Are Early Diagnostic Markers for Ovarian Cancer.

ABSTRACT:

Significance

Measurement of serum FFA levels by changes in the expression of fatty acid metabolizing enzymes in tumor tissue would allow early detection of ovarian cancer. In particular, the SCD1-associated FFAs, oleic and arachidic acid, would be powerful new screening tools for early-stage ovarian cancer.

SUBMITTER: Katoh K

PROVIDER: S-EPMC10498943 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Serum Free Fatty Acid Changes Caused by High Expression of Stearoyl-CoA Desaturase 1 in Tumor Tissues Are Early Diagnostic Markers for Ovarian Cancer.

Katoh Kanoko K Katoh Yuki Y Kubo Akiko A Iida Miho M Ikeda Yuji Y Iwata Takashi T Nishio Hiroshi H Sugawara Masaki M Kato Daiki D Suematsu Makoto M Hirai Shuichi S Kawana Kei K

Cancer research communications 20230901 9

Ovarian cancer has a poor prognosis and is difficult to detect in early stages. Therefore, developing new diagnostic markers for early-stage ovarian cancer is critical. Here, we developed a diagnostic marker for early-stage ovarian cancer on the basis of fatty acid metabolism characteristics of cancer cells. The expression of various fatty acid metabolizing enzymes such as stearoyl-CoA desaturase 1 (SCD1) was altered in early-stage ovarian cancer tissue compared with that in normal ovarian tissu ...[more]

PMID: 37712874

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