Dynamic nucleosome remodeling mediated by YY1 underlies early mouse development.

ABSTRACT: Nucleosome positioning can alter the accessibility of DNA-binding proteins to their cognate DNA elements, and thus its precise control is essential for cell identity and function. Mammalian preimplantation embryos undergo temporal changes in gene expression and cell potency, suggesting the involvement of dynamic epigenetic control during this developmental phase. However, the dynamics of nucleosome organization during early development are poorly understood. In this study, using a low-input MNase-seq method, we show that nucleosome positioning is globally obscure in zygotes but becomes well defined during subsequent development. Down-regulation of the chromatin assembly in embryonic stem cells can partially reverse nucleosome organization into a zygote-like pattern, suggesting a possible l

SUBMITTER: Sakamoto M 

PROVIDER: S-EPMC10499016 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature