Induction of kidney-related gene programs through co-option of SALL1 in mole ovotestes.

ABSTRACT: Changes in gene expression represent an important source of phenotypic innovation. Yet how such changes emerge and impact the evolution of traits remains elusive. Here, we explore the molecular mechanisms associated with the development of masculinizing ovotestes in female moles. By performing integrative analyses of epigenetic and transcriptional data in mole and mouse, we identified the co-option of SALL1 expression in mole ovotestes formation. Chromosome conformation capture analyses highlight a striking conservation of the 3D organization at the SALL1 locus, but an evolutionary divergence of enhancer activity. Interspecies reporter assays support the capability of mole-specific enhancers to activate transcription in urogenital tissues. Through overexpression experiments in transgenic m

SUBMITTER: Schindler M 

PROVIDER: S-EPMC10499028 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature