Molecular markers associated with drug resistance in Plasmodium falciparum parasites in central Africa between 2016 and 2021.

ABSTRACT:

Objectives

The widespread occurrence of anti-malarial drug resistance threatens the current efforts to control malaria in African regions. Molecular marker surveillance helps to track the emergence and spread of drug-resistant malaria cases.

Methods

A total of 237 Plasmodium falciparum infections imported from central Africa to Zhejiang Province, China, between 2016 and 2021, were investigated. Genomic DNA was extracted from blood samples of each patient and nested PCRs was used to detect molecular markers in k13, Pfcrt, and Pfmdr1 genes. The spatial and temporal distributions of the molecular markers were analyzed.

Results

A limited polymorphism of k13 was observed, including two nonsynonymous (D464E and K503E) and five synonymous m

SUBMITTER: Xu W 

PROVIDER: S-EPMC10499197 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature