Phylogenetic inference of the emergence of sequence modules and protein-protein interactions in the ADAMTS-TSL family.

ABSTRACT: Numerous computational methods based on sequences or structures have been developed for the characterization of protein function, but they are still unsatisfactory to deal with the multiple functions of multi-domain protein families. Here we propose an original approach based on 1) the detection of conserved sequence modules using partial local multiple alignment, 2) the phylogenetic inference of species/genes/modules/functions evolutionary histories, and 3) the identification of co-appearances of modules and functions. Applying our framework to the multidomain ADAMTS-TSL family including ADAMTS (A Disintegrin-like and Metalloproteinase with ThromboSpondin motif) and ADAMTS-like proteins over nine species including human, we identify 45 sequence module signatures that are associated with t

SUBMITTER: Dennler O 

PROVIDER: S-EPMC10499240 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature