Summary of methodology used in enterotoxigenic Escherichia coli (ETEC) challenge experiments in weanling pigs and quantitative assessment of observed variability.

ABSTRACT: Postweaning diarrhea in pigs is often caused by the F4 or F18 strains of enterotoxigenic Escherichia coli (ETEC). To evaluate interventions for ETEC, experimental infection via a challenge model is critical. Others have reviewed ETEC challenge studies, but there is a lack of explanation for the variability in responses observed. Our objective was to quantitatively summarize the responses and variability among ETEC challenge studies and develop a tool for sample size calculation. The most widely evaluated response criteria across ETEC challenge studies consist of growth performance, fecal consistency, immunoglobulins, pro-inflammatory cytokines, and small intestinal morphology. However, there is variation in the responses seen following ETEC infection as well as the variabilit

SUBMITTER: Dahmer PL 

PROVIDER: S-EPMC10499306 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature