MiRNome expression analysis in canine diffuse large B-cell lymphoma.

ABSTRACT:

Introduction

Lymphoma is a common canine cancer with translational relevance to human disease. Diffuse large B-cell lymphoma (DLBCL) is the most frequent subtype, contributing to almost fifty percent of clinically recognized lymphoma cases. Identifying new biomarkers capable of early diagnosis and monitoring DLBCL is crucial for enhancing remission rates. This research seeks to advance our knowledge of the molecular biology of DLBCL by analyzing the expression of microRNAs, which regulate gene expression by negatively impacting gene expression via targeted RNA degradation or translational repression. The stability and accessibility of microRNAs make them appropriate biomarkers for the diagnosis, prognosis, and monitoring of diseases.

Methods

We extracted and sequenced microR

SUBMITTER: Elshafie NO 

PROVIDER: S-EPMC10499539 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature