Histological validation of atrial structural remodelling in patients with atrial fibrillation.

ABSTRACT:

Background and aims

This study aimed to histologically validate atrial structural remodelling associated with atrial fibrillation.

Methods and results

Patients undergoing atrial fibrillation ablation and endomyocardial atrial biopsy were included (n = 230; 67 ± 12 years old; 69 women). Electroanatomic mapping was performed during right atrial pacing. Voltage at the biopsy site (Vbiopsy), global left atrial voltage (VGLA), and the proportion of points with fractionated electrograms defined as ≥5 deflections in each electrogram (%Fractionated EGM) were evaluated. SCZtotal was calculated as the total width of slow conduction zones, defined as regions with a conduction velocity of <30 cm/s. Histological factors potentially associated with electroanatomic characteristics were eva

SUBMITTER: Takahashi Y 

PROVIDER: S-EPMC10499545 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature