Epilepsy and long-term risk of arrhythmias.

ABSTRACT:

Background and aims

Previous evidence has mainly supported transient changes in cardiac function during interictal or peri-ictal phases in people with epilepsy, but the long-term risk of cardiac arrhythmias is poorly described. This study aimed to assess the long-term association of epilepsy with cardiac arrhythmias, considering the potential role of genetic predisposition and antiseizure medications (ASMs) in any associations observed.

Methods

This population-based study evaluated UK Biobank data for individuals recruited between 2006 and 2010. Cox proportional hazards models and competing risk models were used to examine the association of epilepsy history with the long-term incidence risk of cardiac arrhythmias and arrhythmias subtypes. Polygenic risk scores (PRS) were ca

SUBMITTER: Wang J 

PROVIDER: S-EPMC10499547 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature