Comparative analyses of monocyte memory dynamics from mice to humans.

ABSTRACT:

Background

Innate monocytes can adopt dynamic "memory" states ranging from low-grade inflammation to pathogenic exhaustion, dependent upon signal strength and history of challenges. Low-grade inflammatory monocytes facilitate the pathogenesis of chronic inflammatory diseases, while exhausted monocytes drive the pathogenesis of severe sepsis. Although clinical and basic studies suggest the conservation of key features of exhausted monocytes from human and murine sepsis, systems analyses of monocyte exhaustion among human and murine monocytes are lacking.

Methods

We performed cross examination of septic monocytes scRNAseq data recently collected from human sepsis patients as well as experimental septic mice, in reference to monocytes experimentally exhausted in vitro. Furtherm

SUBMITTER: Yi Z 

PROVIDER: S-EPMC10499745 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature