Life course, genetic, and neuropathological associations with brain age in the 1946 British Birth Cohort: a population-based study.

ABSTRACT:

Background

A neuroimaging-based biomarker termed the brain age is thought to reflect variability in the brain's ageing process and predict longevity. Using Insight 46, a unique narrow-age birth cohort, we aimed to examine potential drivers and correlates of brain age.

Methods

Participants, born in a single week in 1946 in mainland Britain, have had 24 prospective waves of data collection to date, including MRI and amyloid PET imaging at approximately 70 years old. Using MRI data from a previously defined selection of this cohort, we derived brain-predicted age from an established machine-learning model (trained on 2001 healthy adults aged 18-90 years); subtracting this from chronological age (at time of assessment) gave the brain-predicted age difference (brain-PAD). We test

SUBMITTER: Wagen AZ 

PROVIDER: S-EPMC10499760 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature