TnaA, a trithorax group protein, modulates wingless expression in different regions of the Drosophila wing imaginal disc.

ABSTRACT: wingless expression is exquisitely regulated by different factors and enhancers in the imaginal wing discs of Drosophila melanogaster in four domains: the dorsal band, the dorso-ventral boundary, and the inner and outer ring domains. tonalli is a trithorax group gene that encodes a putative SUMO E3 ligase that binds to chromatin to regulate the expression of its targets, including the Hox genes. However, its role in modulating gene expression is barely known. Here, we show that TnaA modulates the wingless expression at two domains of the wing disc, the dorso-ventral boundary and the inner ring. At first, tonalli interacts genetically with Notch to form the wing margin. In the inner ring domain, TnaA modulates wingless transcription. When the dosage of TnaA increases in or near the inner ri

SUBMITTER: Rosales-Vega M 

PROVIDER: S-EPMC10499800 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature