Ontology highlight
ABSTRACT:
SUBMITTER: Salimando GJ
PROVIDER: S-EPMC10499891 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Salimando Gregory J GJ Tremblay Sébastien S Kimmey Blake A BA Li Jia J Rogers Sophie A SA Wojick Jessica A JA McCall Nora M NM Wooldridge Lisa M LM Rodrigues Amrith A Borner Tito T Gardiner Kristin L KL Jayakar Selwyn S SS Singeç Ilyas I Woolf Clifford J CJ Hayes Matthew R MR De Jonghe Bart C BC Bennett F Christian FC Bennett Mariko L ML Blendy Julie A JA Platt Michael L ML Creasy Kate Townsend KT Renthal William R WR Ramakrishnan Charu C Deisseroth Karl K Corder Gregory G
Nature communications 20230913 1
With concurrent global epidemics of chronic pain and opioid use disorders, there is a critical need to identify, target and manipulate specific cell populations expressing the mu-opioid receptor (MOR). However, available tools and transgenic models for gaining long-term genetic access to MOR+ neural cell types and circuits involved in modulating pain, analgesia and addiction across species are limited. To address this, we developed a catalog of MOR promoter (MORp) based constructs packaged into ...[more]