The effects of a 6-month weight loss intervention on physical function and serum biomarkers in older adults with and without osteoarthritis.

ABSTRACT:

Objective

To examine the effects of a 6-month weight loss intervention on physical function, inflammatory biomarkers, and metabolic biomarkers in both those with and without osteoarthritis (OA).

Design

59 individuals ≥60 years old with obesity and a functional impairment were enrolled into this IRB approved clinical trial and randomized into one of two 6-month weight loss arms: a higher protein hypocaloric diet or a standard protein hypocaloric diet. All participants were prescribed individualized 500-kcal daily-deficit diets, with a goal of 10% weight loss. Additionally, participants participated in three, low-intensity, exercise sessions per week. Physical function, serum biomarkers and body composition data were assessed at the baseline and 6-month timepoints. Statistical

SUBMITTER: Coppock JA 

PROVIDER: S-EPMC10499923 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature