Inherited CD19 Deficiency Does Not Impair Plasma Cell Formation or Response to CXCL12.

ABSTRACT:

Background

The human CD19 antigen is expressed throughout B cell ontogeny with the exception of neoplastic plasma cells and a subset of normal plasma cells. CD19 plays a role in propagating signals from the B cell receptor and other receptors such as CXCR4 in mature B cells. Studies of CD19-deficient patients have confirmed its function during the initial stages of B cell activation and the production of memory B cells; however, its role in the later stages of B cell differentiation is unclear.

Objective

Using B cells from a newly identified CD19-deficient individual, we investigated the role of CD19 in the generation and function of plasma cells using an in vitro differentiation model.

Methods

Flow cytometry and long-read nanopore sequencing using locus-specific long

SUBMITTER: Walker K 

PROVIDER: S-EPMC10499936 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature