The context-dependent role of the Na⁺/Ca²⁺-exchanger (NCX) in pancreatic stellate cell migration.

ABSTRACT: Pancreatic stellate cells (PSCs) that can co-metastasize with cancer cells shape the tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC) by producing an excessive amount of extracellular matrix. This leads to a TME characterized by increased tissue pressure, hypoxia, and acidity. Moreover, cells within the tumor secrete growth factors. The stimuli of the TME trigger Ca²⁺ signaling and cellular Na⁺ loading. The Na⁺/Ca²⁺ exchanger (NCX) connects the cellular Ca²⁺ and Na⁺ homeostasis. The NCX is an electrogenic transporter, which shuffles 1 Ca²⁺ against 3 Na⁺ ions over the plasma membrane in a forward or reverse mode. Here, we studied how the impact of NCX activity on PSC migration is m

SUBMITTER: Loeck T 

PROVIDER: S-EPMC10499968 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature