Differential abundance of lipids and metabolites related to SARS-CoV-2 infection and susceptibility.

ABSTRACT: The mechanisms driving SARS-CoV-2 susceptibility remain poorly understood, especially the factors determining why unvaccinated individuals remain uninfected despite high-risk exposures. To understand lipid and metabolite profiles related with COVID-19 susceptibility and disease progression. We collected samples from an exceptional group of unvaccinated healthcare workers heavily exposed to SARS-CoV-2 but not infected ('non-susceptible') and subjects who became infected during the follow-up ('susceptible'), including non-hospitalized and hospitalized patients with different disease severity providing samples at early disease stages. Then, we analyzed their plasma metabolomic profiles using mass spectrometry coupled with liquid and gas chromatography. We show specific lipids profiles and met

SUBMITTER: Alboniga OE 

PROVIDER: S-EPMC10500013 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature