A recommended preclinical extracorporeal cardiopulmonary resuscitation model for neurological outcomes: A scoping review.

ABSTRACT:

Background

Despite the high prevalence of neurological complications and mortality associated with extracorporeal cardiopulmonary resuscitation (ECPR), neurologically-focused animal models are scarce. Our objective is to review current ECPR models investigating neurological outcomes and identify key elements for a recommended model.

Methods

We searched PubMed and four other engines for animal ECPR studies examining neurological outcomes. Inclusion criteria were: animals experiencing cardiac arrest, ECPR/ECMO interventions, comparisons of short versus long cardiac arrest times, and neurological outcomes.

Results

Among 20 identified ECPR animal studies (n = 442), 13 pigs, 4 dogs, and 3 rats were used. Only 10% (2/20) included both sexes. Significant heterogeneity

SUBMITTER: Kook Kang J 

PROVIDER: S-EPMC10500026 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature