Disconnectome associated with progressive white matter hyperintensities in aging: a virtual lesion study.

ABSTRACT:

Objective

White matter hyperintensities (WMH) are commonly seen on T2-weighted magnetic resonance imaging (MRI) in older adults and are associated with an increased risk of cognitive decline and dementia. This study aims to estimate changes in the structural connectome due to age-related WMH by using a virtual lesion approach.

Methods

High-quality diffusion-weighted imaging data of 30 healthy subjects were obtained from the Human Connectome Project (HCP) database. Diffusion tractography using q-space diffeomorphic reconstruction (QSDR) and whole brain fiber tracking with 10⁷ seed points was conducted using diffusion spectrum imaging studio and the brainnetome atlas was used to parcellate a total of 246 cortical and subcortical nodes. Previously published WMH frequ

SUBMITTER: Li M 

PROVIDER: S-EPMC10500060 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature