Noninvasive drug adherence monitoring of antipsychotic patients via finger sweat testing.

ABSTRACT: Collection of finger sweat is explored here as a rapid and convenient way of monitoring patient adherence to antipsychotic drugs. Finger sweat samples (n = 426) collected from patients receiving treatment with clozapine, quetiapine and olanzapine were analysed by liquid chromatography mass spectrometry, including a subgroup of patients with paired plasma samples. Finger sweat samples were also analysed from a negative control group and patients who had handled antipsychotic medication only. The finger sweat test (based on the detection of parent drug in one donated sample) was 100% effective in monitoring adherence within commonly prescribed dosing ranges. In comparison to participants who handled the medication only, the test could distinguish between contact and administration thr

SUBMITTER: Longman K 

PROVIDER: S-EPMC10500062 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature