Metagenomic next-generation sequencing assistance in identifying non-tuberculous mycobacterial infections.

ABSTRACT:

Introduction

The advent of metagenomics next-generation sequencing (mNGS) has garnered attention as a novel method for detecting pathogenic infections, including Non-Tuberculous Mycobacterial (NTM) and tuberculosis (TB).However, the robustness and specificity of mNGS in NTM diagnostics have not been fully explored.

Methods

In this retrospective study, we enrolled 27 patients with NTM genomic sequences via mNGS and conducted a comprehensive clinical evaluation.

Results

Pulmonary NTM disease was the most commonly observed presentation, with a subset of patients also presenting with extrapulmonary NTM infections.mNGS analysis identified six distinct NTM species, primarily Mycobacteriumavium complex (MAC), followed by Mycobacterium intracellulare andMycobacterium abscessu

SUBMITTER: Wang S 

PROVIDER: S-EPMC10500063 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature