FunTaxIS-lite: a simple and light solution to investigate protein functions in all living organisms.

ABSTRACT:

Motivation

Defining the full domain of protein functions belonging to an organism is a complex challenge that is due to the huge heterogeneity of the taxonomy, where single or small groups of species can bear unique functional characteristics. FunTaxIS-lite provides a solution to this challenge by determining taxon-based constraints on Gene Ontology (GO) terms, which specify the functions that an organism can or cannot perform. The tool employs a set of rules to generate and spread the constraints across both the taxon hierarchy and the GO graph.

Results

The taxon-based constraints produced by FunTaxIS-lite extend those provided by the Gene Ontology Consortium by an average of 300%. The implementation of these rules significantly reduces errors in function predictions made b

SUBMITTER: Bianca F 

PROVIDER: S-EPMC10500080 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature