Reducing cost in DNA-based data storage by sequence analysis-aided soft information decoding of variable-length reads.

ABSTRACT:

Motivation

DNA-based data storage is one of the most attractive research areas for future archival storage. However, it faces the problems of high writing and reading costs for practical use. There have been many efforts to resolve this problem, but existing schemes are not fully suitable for DNA-based data storage, and more cost reduction is needed.

Results

We propose whole encoding and decoding procedures for DNA storage. The encoding procedure consists of a carefully designed single low-density parity-check code as an inter-oligo code, which corrects errors and dropouts efficiently. We apply new clustering and alignment methods that operate on variable-length reads to aid the decoding performance. We use edit distance and quality scores during the sequence analysis-aided

SUBMITTER: Park SJ 

PROVIDER: S-EPMC10500082 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature