Genome-wide multimediator analyses using the generalized Berk-Jones statistics with the composite test.

ABSTRACT:

Motivation

Mediation analysis is performed to evaluate the effects of a hypothetical causal mechanism that marks the progression from an exposure, through mediators, to an outcome. In the age of high-throughput technologies, it has become routine to assess numerous potential mechanisms at the genome or proteome scales. Alongside this, the necessity to address issues related to multiple testing has also arisen. In a sparse scenario where only a few genes or proteins are causally involved, conventional methods for assessing mediation effects lose statistical power because the composite null distribution behind this experiment cannot be attained. The power loss hence decreases the true mechanisms identified after multiple testing corrections. To fairly delineate a uniform distribution

SUBMITTER: Lai EY 

PROVIDER: S-EPMC10500087 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature