Exogenous Spermidine Alleviates Diabetic Myocardial Fibrosis Via Suppressing Inflammation and Pyroptosis in db/db Mice

ABSTRACT:

Background

The main pathological feature of diabetic cardiomyopathy (DCM) caused by diabetes mellitus is myocardial fibrosis. According to recent studies in cardiology, it has been suggested that spermidine (SPD) has cardioprotective properties.

Aims

To explore the role and mechanism of SPD in alleviating myocardial fibrosis of DCM.

Study design

In vivo and in vitro study.

Methods

Type 2 diabetic mice and primary neonatal mouse cardiac fibroblasts (CFs) were selected. Measurements of serum-related markers, echocardiographic analysis, and immunohistochemistry were used to evaluate myocardial fibrosis injury and the effects of SPD. The proliferation and migration of CFs undergoing different treatments were studied. Immunoblotting and real-time quantitative revers

SUBMITTER: Wei C 

PROVIDER: S-EPMC10500142 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature