Borna disease in a dog with lethal meningoencephalitis.

ABSTRACT: A dog was euthanatized because of progressive neurological signs. Histologically, a nonsuppurative meningoencephalitis was found. By immunohistochemistry, in situ hybridization, and nested PCR procedures, Borna disease virus (BDV) antigen and BDV-specific RNA were demonstrated in brain tissues of the dog. The nucleotide sequence of the PCR product showed 94 to 98% homology to published BDV sequences. This is the first description of Borna disease in a dog.

SUBMITTER: Weissenbock H 

PROVIDER: S-EPMC105002 | biostudies-literature | 1998 Jul

REPOSITORIES: biostudies-literature