Prognostic value and immune landscapes of immunogenic cell death-related lncRNAs in hepatocellular carcinoma.

ABSTRACT:

Background

Both immunogenic cell death (ICD) and long noncoding RNAs (lncRNAs) are strongly associated with tumor development, but the mechanism of action of ICD-associated lncRNAs in hepatocellular carcinoma (HCC) remains unclear.

Methods

We collected data from 365 HCC patients from The Cancer Genome Atlas (TCGA) database. We formulated a prognostic signature of ICD-associated lncRNAs and a nomogram to predict prognosis. To explore the potential mechanisms and provide clinical guidance, survival analysis, enrichment analysis, tumor microenvironment analysis, tumor mutation burden (TMB), and drug sensitivity prediction were conducted based on the subgroups obtained from the risk score.

Results

A prognostic signature of seven ICD-associated lncRNAs was constructed. Kap

SUBMITTER: Chen W 

PROVIDER: S-EPMC10500227 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature